Our studies is anything less than 1 and a 1/2 or so milligrams of THC in a survey. And just as a way of example, the very first custom formulated first time ever actually that it's ever been done, we had the very first whole plant full spectrum high hemp gel, low, but not no, THC sublingual solution for folks with anxiety. We're doing that at McLean right now, come sign up. hemp seed oil capsules a great study, open-label phase is complete, double-blind is underway. But when I say low dose, what I mean is each milliliter, so each ml like a dropper full. that our patients take has less than 0.3 mg of THC. So it's a three-times-a-day dosing schedule, they actually get less than one milligram per day. That to me is a low dose, that to me. I'm conservative, you can always add, you can never take it away, once it's in,. So just remember that, but low dose, I tend to think of lower doses as less than two milligrams, sort of. - So there are a ton of studies out there about marijuana use in younger people, and I know that MIND has done a lot of them as well but is anybody studying the effects of regular marijuana use in older adults? - So I just realized I could hit the space bar, and temporarily I can mute myself. Look at that, high-tech. So there've been a lot of studies looking at the impact of cannabis on the developing brain to your point, and the ABCD Initiative is actually collecting data on over 11,000 healthy, 9 and 10-year-olds. And we'll follow them prospectively to look at the ways in which cannabis.
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As well as other substances, alcohol, et cetera, change the ways our brain develops, et cetera. So to your point, the idea of looking at the impact of cannabis use in older adults is critically important. There are not nearly enough data at this point. We actually have a study funded by NIDA to look at the impact of cannabis use in older adults with chronic pain who decide to use or to add medical cannabis to their regimen, versus those who don't. The reason it's so important to look at older adults, older adults are the fastest growing consumer group of cannabis users in the country. So whosever asked this question, kudos to you, thank you, I feel like I owe you a check. The numbers are really quite staggering and you can understand why, but hemp seed oil capsules a very, very important cohort to look at and yet we have very, very little data. And again, this hemp gel group.
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It also really, really interesting and important because of potential drug-drug interactions, which we know very little about, and things like reduced metabolism. And the idea is that very often our older patients at least in our longitudinal studies, very often our older patients are not interested in using methods or modes of use that include things like inhalation. They're not looking to vape or smoke, they tend to gravitate towards ingestible forms of the product, and you've all heard stories about quote, "inadvertently" having too much, it was a half a cookie, how high could I be? But the answer is very high and that's a problem, but it feels a little bit less like you're using quote "drugs." For some people if they're using ingestibles, whether it's a beverage or a consumable, or even a lozenge. So it's a very, very important thing to study in individuals over 55, 65, every tier. Again given changes in metabolism, drug-drug interactions, the fact that you choose a route of administration that has what we call the longest rise time. hemp seed oil capsules absolutely takes the longest time to get an effect when you use something that's a consumable, not just edible but consumable, sometimes up to two hours. So in that two hour period, what we often hear is, ugh, I'm sure I could have more, I'm obviously, I'm immune to hemp gel, I better take more. Well, then it's a very big problem
Raz Smiths
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